The Minnesota Vikings remain the NFL's only unbeaten team heading into Week 8, where they will visit the Detroit Lions as 3.5-point underdogs on Sunday. Several other matchups feature one-loss teams, including the 5-1 Kansas City Chiefs facing the Denver Broncos as 1.5-point underdogs, and the Baltimore Ravens hosting the 5-1 Buffalo Bills as 3-point favorites with quarterback Lamar Jackson returning from an ankle injury that sidelined him for three games.
Week 8 also includes a slate of divisional games: the Atlanta Falcons at the Tampa Bay Buccaneers (-2.5), the Cleveland Browns at the Pittsburgh Steelers (-3.5), the Indianapolis Colts at the Jacksonville Jaguars (-10), the New England Patriots at the Miami Dolphins (+7), and the Philadelphia Eagles at the Washington Commanders (-5.5) on Sunday Night Football. The Patriots and Chiefs are the only road favorites this week.
A computer model that simulates every NFL game 10,000 times has produced five best bets for Week 8, offering a combined parlay payout of nearly 25-1. The model, which has returned more than $5,000 for $100 players on top-rated picks since its inception, entered the week on a 58-51 run on top-rated selections dating back to 2024.
Among the model's top picks is the Over 46.5 points in the Colts-Jaguars matchup, which hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, is 6-4 in the last 10 Indianapolis games, and hit in Jacksonville's most recent contest. Jacksonville ranks seventh in scoring at 25.7 points per game, tied with the Chicago Bears, while Indianapolis allows 25.7 points per game and recently traded defensive lineman DeForest Buckner.
Indianapolis relies heavily on running back Jonathan Taylor, who has rushed 140 times for 587 yards (4.2 average) and eight touchdowns in seven games. Quarterback Daniel Jones has completed 59.6% of his passes for 1,398 yards, four touchdowns, and seven interceptions. For Jacksonville, Trevor Lawrence has completed 65.2% of his passes for 1,480 yards, 14 touchdowns, and four interceptions with a 106.3 passer rating in six starts. Wide receiver Parker Washington has 26 receptions for 416 yards (16.0 average) and four touchdowns.
The model also identifies four additional matchups where it believes the line is significantly off, including multiple spread picks that hit well over 50% of the time in simulations. The full set of Week 8 best bets and parlay details are available through the model's subscription service.
