All 16 NFL Week 8 games will be played domestically, featuring several potential postseason rematches. Key matchups include the Ravens at Bills (-3), Vikings at Lions (-3.5), Chiefs at Broncos (+1.5), and Bears at Seahawks (-3).
Computer Model Projections
An advanced computer model simulating each game 10,000 times has generated betting picks for every matchup. Since its inception, the model has returned more than $5,000 for $100 players on top-rated NFL picks and entered Week 8 on a 58-51 run on top-rated selections dating back to 2024.
Top Week 8 Picks
The model's strongest pick has the Steelers (-3.5, total 39) covering at home against the Browns. Pittsburgh has won 22 consecutive home games versus Cleveland dating back to 2004 and is 3-0 against the spread at home this season, while the Browns are 2-2 ATS on the road. The model projects Pittsburgh to cover well over 60% of the time.
Another high-confidence selection is the Rams (-6.5, total 45.5) covering against the Chargers. Los Angeles has lost nine straight games dating to last season, with quarterback Justin Herbert recording 12 turnovers against six touchdowns over that span. The Chargers are also winless against the spread during the streak, while the Rams are 6-2 ATS in non-conference games since 2025. The model predicts a touchdown-plus victory for Los Angeles with the over hitting 55% of simulations.
Other Notable Lines
Games with large point spreads include Bengals (-13.5) vs. Titans, Jaguars (-10.5) vs. Colts, and Rams (-6.5) vs. Chargers. The Chiefs are slight favorites at -1.5 over the Broncos, while the Patriots are -7 against the Dolphins and the Eagles are -6 versus the Commanders.
The Chargers remain the only winless team against the spread this season, and every team has at least two ATS defeats. The model also projects six teams to win by double digits, offering potential value on alternate lines.
