College football Week 10 features a loaded slate of marquee matchups, with oddsmakers releasing opening lines for all major games. The highlight is No. 1 Miami traveling to No. 5 Notre Dame, where the Fighting Irish opened as 4.5-point favorites despite a loss to BYU earlier this season.
Top Matchups
No. 1 Miami at No. 5 Notre Dame (-4.5): The Hurricanes narrowly escaped Florida State and North Carolina, with their secondary allowing 341 passing yards to North Carolina's Billy Edwards Jr. Notre Dame, coming off a loss to BYU, remains in playoff contention but would have zero margin for error with a loss.
No. 10 Alabama at No. 15 LSU (-3.5): The Crimson Tide have won six of the last seven meetings in Baton Rouge. Alabama quarterback Keelon Russell struggled on the road at Tennessee, while LSU seeks to avoid a third loss.
Oregon at No. 2 Ohio State (-10.5): Ohio State is a two-score favorite despite a loss to USC. The Buckeyes may start freshman quarterback Luke Fahey, while Oregon's Dylan Raiola has shown inconsistency.
No. 8 BYU at No. 6 Utah (-4.5): The Holy War kicks off at 10 a.m. local time with both teams eyeing a Big 12 title and playoff berth. BYU has won three straight in the series but has not been at its best since beating Notre Dame.
No. 3 Georgia at No. 12 Ole Miss (-3.5): Georgia's passing attack was ineffective in a win over Florida, giving Ole Miss a chance to pull an upset at home behind quarterback Trinidad Chambliss.
No. 11 Texas at No. 23 Missouri (-3.5): Texas faces a Missouri team with an explosive passing game led by Austin Simmons and a returning running back Ahmad Hardy, who recovered from a gunshot wound.
No. 9 Kentucky at No. 16 Tennessee (-6.5): Kentucky aims to prove its playoff credentials in a hostile Neyland Stadium, while Tennessee's offense looks to rebound after quarterback George MacIntyre's late-game struggles against South Carolina.
Other Notable Games
Virginia Tech at No. 19 SMU (-6.5), Michigan State at Michigan (-13.5), No. 7 UCLA at Minnesota (-5.5), Texas A&M at South Carolina (-6.5), Penn State at Washington (-1.5), Cincinnati at No. 18 Houston (-10.5), Iowa at No. 20 Northwestern (-1.5), Oklahoma at Florida (-6.5).
