The Philadelphia 76ers (7-1) and Detroit Pistons (6-1), the top two teams in the Eastern Conference, meet Wednesday at 7 p.m. ET at Little Caesars Arena in Detroit. The Sixers have won four straight, most recently a 126-107 victory over Chicago on Monday. The Pistons have won three straight, including a 124-91 win over Charlotte on Monday. Detroit has won six consecutive meetings against Philadelphia, including a 240-point combined total in their last matchup in Detroit on Oct. 25, which was the 76ers' only loss this season.
Detroit enters as a 2.5-point favorite with an over/under of 219.5 points. The money line lists the Pistons at -135 and the 76ers at +120. The SportsLine Projection Model, which has returned nearly $19,000 in profit for $100 players on top-rated NBA picks since 2018, simulated the game 10,000 times and projects the total to go Over 219.5. The model forecasts 220 total points, citing both teams' recent offensive output and a trend of high-scoring games in Detroit, where the Over is 11-5 in the last 16 meetings. With Pistons center Jalen Duren out, three 76ers players are projected to reach 20 points, while four of Detroit's five starters are expected to exceed their scoring averages.
The model also indicates one side of the spread hits in well over 50% of simulations. Detailed picks are available via SportsLine. The game will be streamed on Fubo.

