Week 10 college football odds feature numerous one-score lines, reflecting seven matchups between teams that appeared in the initial College Football Playoff rankings.
In the SEC, Alabama visits LSU as a 6-point underdog, Georgia travels to Ole Miss with a 3.5-point spread, and Texas faces Missouri at +2.5. Elsewhere, the top-ranked Miami Hurricanes visit No. 11 Notre Dame, where the Fighting Irish are 7-point favorites seeking revenge for last year's loss. Miami will be without injured star wide receiver Malachi Toney due to an ankle injury.
Out west, the BYU-Utah rivalry resumes with the third-ranked Utes favored by 4.5 points at home. The series dates back over 100 years, and BYU seeks a fourth consecutive win over Utah.
A proven computer model that simulates every FBS game 10,000 times entered Week 10 with an 80-77 record on top-rated picks this season. The model has locked in picks for every FBS matchup.
One top recommendation has Ohio State (-7.5, 45.5) covering against Oregon in a 3:30 p.m. ET kickoff. Ohio State, coming off a loss at USC, is expected to benefit from freshman quarterback Luke Fahey's comfort at home against an Oregon defense that has allowed more passing touchdowns than all but three Big Ten teams. The Buckeyes have covered in 80% of home games since the start of 2025 and are projected to win by double digits, covering more than 60% of the time.
Another pick favors Oklahoma (+5.5, 45.5) to cover at Florida. The Gators have lost three of their last four games, each by 19 or more points. Florida's quarterback situation remains unstable after Aaron Philo was benched against Georgia and his replacement Tramell Jones committed two turnovers. Oklahoma, by contrast, has stability with quarterback John Mateer averaging 296.5 total yards, four passing touchdowns, and zero turnovers over the last two games. Florida leads the SEC in penalty yards, and the model projects the Over to hit in 59% of simulations.
The model also projects three upsets in ranked matchups according to the poll rankings. Full picks for every game are available from the model's projections.
Notable Week 10 Games
Saturday, Nov. 7:
BYU at Utah (-4.5, 49.5)
Texas at Missouri (+2.5, 42.5)
UCLA at Minnesota (+3.5, 38.5)
Alabama at LSU (-6, 52.5)
Oregon at Ohio State (-7.5, 45.5)
Kentucky at Tennessee (-6, 49.5)
Air Force at Army (-4, 43.5)
Miami at Notre Dame (-7, 54.5)
Michigan State at Michigan (-14, 39.5)
Georgia at Ole Miss (+3.5, 56.5)
Oklahoma at Florida (-5.5, 45.5)
