NFL Week 9 score predictions highlight several key trends and expert picks for the upcoming schedule. A notable pattern emerges in the Seattle Seahawks' matchup against the Arizona Cardinals, where four of the last five meetings in Seattle have been decided by exactly 10 points. The Seahawks have won 10 straight meetings against the Cardinals regardless of location, and enter Sunday's game as 8.5-point favorites, with the line dropping from an opening 12.5 points due to quarterback changes: Drew Lock starts for Seattle in place of the injured Sam Darnold, while Gardner Minshew will quarterback Arizona.
Other notable spreads
Games with spreads of at least a touchdown include the Detroit Lions vs. Miami Dolphins (+6.5), San Francisco 49ers vs. Las Vegas Raiders (+9.5), and Kansas City Chiefs vs. New York Jets (+9.5).
Expert analysis
NFL expert Eric Cohen, who finished the 2025-26 season with a 188-96-1 straight-up record (66%) and is 70-50-1 (58%) on 2026 picks, projects the 49ers to defeat the Raiders 34-24 while the over hits on the 51.5-point total. San Francisco is 8-1 straight-up following their last nine bye weeks, while the Raiders are 1-5 over their last six with a rest disadvantage. The 49ers rank sixth in scoring defense compared to Las Vegas at 31st, and six straight Raiders games have seen 56 or more points. Cohen also identifies five games projected to be decided by 13 or more points, which could provide significant returns on alternate lines.
