No. 12 Ohio State hosts No. 23 Oregon in a Big Ten showdown on Saturday at 3:30 p.m. ET from Ohio Stadium in Columbus, Ohio. The Buckeyes enter at 6-2 overall and 4-1 in conference play after a five-game winning streak ended with a 30-18 loss to unranked USC. The Ducks are 5-3 overall and 3-2 in the Big Ten following a 34-26 upset of then-No. 20 Northwestern.
Both teams will be without their starting quarterbacks. Ohio State's Julian Sayin is out with an arm injury, while Oregon's Dante Moore is sidelined with a concussion. Buckeyes receiver Brandon Inniss is listed as doubtful.
Ohio State opens as a 7.5-point favorite with an over/under of 44.5 points. The money line lists Ohio State at -294 and Oregon at +245.
A projection model simulating the game 10,000 times leans toward the over on the total. The last four meetings between the programs have all surpassed 60 combined points. The over has hit in all four Ohio State home games in 2026 and in two of three Oregon road games. Oregon's last six games as an underdog have seen the over cash 5-1. Backup quarterbacks performed well last week: Oregon's Dylan Raiola threw for 336 yards and three touchdowns, while Ohio State true freshman Luke Fahey posted 260 yards, one touchdown and zero turnovers at USC. The model projects over 500 combined passing yards and sees the over hitting in 56% of simulations.
The model also indicates one side of the spread hits in over 60% of simulations. Entering Week 10, the model held an 80-77 record on top-rated college football picks.
