The Buffalo Bills and Minnesota Vikings, both 6-1 and leading their respective divisions, meet on Monday Night Football at U.S. Bank Stadium in Minneapolis. Kickoff is set for 8:15 p.m. ET.
The Bills enter after a 36-10 win over Baltimore on Nov. 1, while the Vikings suffered their first loss, 19-15 at Detroit the same day. Buffalo is 3-0 on the road in 2026; Minnesota is 3-0 at home.
Injury report: Vikings will be without quarterback Kyler Murray (hamstring) and receiver Jauan Jennings. Bills receiver Joshua Palmer (hamstring) is out and headed to injured reserve.
Betting odds: Buffalo is a 3.5-point favorite, over/under 45.5 points, money line Bills -186, Vikings +165.
SportsLine's simulation model, which has returned over $5,000 for $100 players on top-rated NFL picks since inception, projects the Over 45.5 points as the slight value side. The Over has hit in three of the last four Bills games and in three of the last four matchups in Minnesota. The model also indicates one side of the spread hits in more than 50% of simulations.
Key projections: Carson Wentz's insertion at quarterback is expected to boost Minnesota's offense, with three Vikings projected to top 60 scrimmage yards. Josh Allen and James Cook are projected to combine for nearly 125 rushing yards.
