NFL Week 9 score predictions highlight several key matchups with notable trends. The Seattle Seahawks host the Arizona Cardinals on Sunday at 4:25 p.m. ET, with four of their last five meetings in Seattle decided by exactly 10 points. Seattle is an 8.5-point favorite, down from an opening line of 12.5 points, with Drew Lock starting in place of injured Sam Darnold. The Seahawks have won 10 straight meetings against the Cardinals.
Other notable spreads
Games with spreads of at least a touchdown include the Detroit Lions vs. Miami Dolphins (+6.5), San Francisco 49ers vs. Las Vegas Raiders (+9.5), and Kansas City Chiefs vs. New York Jets (+9.5).
Expert analysis
Analyst Eric Cohen, who finished the 2025-26 season with a 188-96-1 straight-up record (66%) and is 70-50-1 (58%) on 2026 picks, projects the 49ers to defeat the Raiders 34-24. San Francisco is 8-1 straight-up following their last nine bye weeks, while the Raiders are 1-5 over their last six with a rest disadvantage. Both teams have top-6 scoring offenses, but Las Vegas ranks 31st in scoring defense compared to San Francisco's 6th. Cohen notes six straight Raiders games have seen 56 or more points, supporting the over on a 51.5 total.
Additional predictions
Cohen has identified five games projected to be decided by 13 or more points, which could provide significant returns on alternate lines. His full Week 9 score predictions are available through his platform.
