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College Football Week 10 Odds and Model Predictions Highlight Top Matchups

College Football Week 10 Odds and Model Predictions Highlight Top Matchups
World Sports · 10:10:59 - Saturday, 14 November 2026

Week 10 of the college football season features seven matchups between teams in the initial College Football Playoff rankings, with several one-score lines across major conferences. In the SEC, Alabama visits LSU as a 6-point underdog, Georgia travels to Ole Miss as a 3.5-point underdog, and Texas faces Missouri as a 2.5-point underdog. The top non-conference clash sees No. 1 Miami visiting No. 11 Notre Dame, with the Fighting Irish favored by 7 points while the Hurricanes will be without injured wide receiver Malachi Toney. In a historic rivalry, BYU seeks a fourth straight win over Utah, with the Utes favored by 4.5 points at home.

Model Predictions for Key Games

SportsLine's computer model, which simulates every FBS game 10,000 times and entered the week with an 80-77 record on top-rated picks, projects Ohio State to cover as a 7.5-point favorite against Oregon. The Buckeyes, coming off a loss at USC, are projected to win by double digits at home, covering in over 60% of simulations. The model also favors Oklahoma to cover as a 5.5-point underdog at Florida, citing quarterback stability with John Mateer and Florida's penalty issues. The Over in that game hits in 59% of simulations.

Week 10 Notable Game Odds

Saturday, Nov. 7 lines include: BYU at Utah (-4.5, 49.5), Texas at Missouri (+2.5, 42.5), UCLA at Minnesota (+3.5, 38.5), Alabama at LSU (-6, 52.5), Oregon at Ohio State (-7.5, 45.5), Kentucky at Tennessee (-6, 49.5), Air Force at Army (-4, 43.5), Miami at Notre Dame (-7, 54.5), Michigan State at Michigan (-14, 39.5), Georgia at Ole Miss (+3.5, 56.5), Oklahoma at Florida (-5.5, 45.5). The model projects three upsets in ranked matchups.

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