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Prisco's Week 10 NFL Picks: Lions Favored Over Patriots in Munich, Cowboys Upset 49ers

Prisco's Week 10 NFL Picks: Lions Favored Over Patriots in Munich, Cowboys Upset 49ers
Articles · 10:12:54 - Sunday, 15 November 2026

CBS Sports columnist Pete Prisco enters Week 10 with a 15-0 straight-up record from the previous week and a 9-6 mark against the spread, bringing his season totals to 87-48-1 straight up and 59-74-3 ATS. He offers predictions for every game, including the international matchup in Munich.

In the Sunday 9:30 a.m. ET kickoff from Munich, Prisco takes the Detroit Lions (-2.5) over the New England Patriots, projecting a 30-24 Lions victory. He cites New England's defensive struggles after a blowout loss to Green Bay and expects Detroit's offense to rebound.

Other notable picks: Kansas City Chiefs (-3.5) over Atlanta Falcons (23-17); Houston Texans over Cleveland Browns (+4.5) (21-20); Green Bay Packers (-3.5) over Minnesota Vikings (27-17); Jacksonville Jaguars (-10.5) over Tennessee Titans (31-17); Indianapolis Colts over Miami Dolphins (+3.5) (23-22); New Orleans Saints (-2.5) over Carolina Panthers (24-21); Buffalo Bills (-8.5) over New York Jets (34-21); Seattle Seahawks (-6.5) over Las Vegas Raiders (24-16); Los Angeles Rams over Arizona Cardinals (+9.5) (19-16); Dallas Cowboys (+4.5) over San Francisco 49ers in an upset special (30-28); Cincinnati Bengals (-3.5) over Pittsburgh Steelers (27-21); Baltimore Ravens over Los Angeles Chargers (+4.5) (20-17); and New York Giants (-2.5) over Washington Commanders in the Thursday night game (23-14).

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