The Minnesota Vikings remain the NFL's only unbeaten team and will put their perfect record on the line Sunday when they visit the Detroit Lions, who are favored by 3.5 points. Other games featuring one-loss teams include the 5-1 Kansas City Chiefs against the Denver Broncos (+1.5) and the Baltimore Ravens versus the 5-1 Buffalo Bills (-3), with Ravens quarterback Lamar Jackson trending toward a return from an ankle injury.
Week 8 also features several divisional matchups: the Atlanta Falcons at the Tampa Bay Buccaneers (-2.5), the Cleveland Browns at the Pittsburgh Steelers (-3.5), the Indianapolis Colts at the Jacksonville Jaguars (-10), the New England Patriots at the Miami Dolphins (+7), and the Philadelphia Eagles at the Washington Commanders (-5.5) on Sunday Night Football.
A computer model that simulates every NFL game 10,000 times has identified five confident best bets for Week 8. The model, which has returned more than $5,000 for $100 players on top-rated picks since its inception, entered the week on a 58-51 run on top-rated selections dating back to 2024. A successful parlay of the model's five picks would pay nearly 25-1.
The model's top pick is the Over 46.5 points in the Colts-Jaguars game, which hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, is 6-4 in the last 10 Indianapolis games, and hit in Jacksonville's most recent contest. Jacksonville ranks seventh in the NFL in scoring, tied with the Chicago Bears at 25.7 points per game, while Indianapolis allows 25.7 points per game and recently traded defensive lineman DeForest Buckner.
The Colts' offense is led by running back Jonathan Taylor, who has rushed 140 times for 587 yards (4.2 average) and eight touchdowns in seven games. Quarterback Daniel Jones has completed 59.6% of his passes for 1,398 yards, four touchdowns, and seven interceptions. For Jacksonville, quarterback Trevor Lawrence has completed 65.2% of his passes for 1,480 yards, 14 touchdowns, four interceptions, and a 106.3 passer rating in six starts. Wide receiver Parker Washington has 26 receptions for 416 yards (16.0 average) and four touchdowns.
The model also highlights four other matchups where it believes the line is significantly off, including multiple spread picks that hit well over 50% of the time in simulations.
