The Minnesota Vikings enter Week 8 as the NFL's last unbeaten team and will test that record on the road against the Detroit Lions, who are favored by 3.5 points. Other notable matchups featuring one-loss teams include the 5-1 Kansas City Chiefs visiting the Denver Broncos (+1.5) and the Baltimore Ravens hosting the 5-1 Buffalo Bills (-3), with quarterback Lamar Jackson trending toward a return from an ankle injury. Several divisional games highlight the slate, including Falcons at Buccaneers (-2.5), Browns at Steelers (-3.5), Colts at Jaguars (-10), Patriots at Dolphins (+7), and Eagles at Commanders (-5.5) on Sunday Night Football.
A proven computer model from SportsLine, which simulates every NFL game 10,000 times, has identified five confident best bets for Week 8. The model entered the week on a 58-51 run on top-rated picks dating back to 2024 and has returned more than $5,000 for $100 players on betting sites since its inception. A successful parlay of the model's five selections would pay nearly 25-1.
The model's top pick is the Over 46.5 points in the Indianapolis Colts vs. Jacksonville Jaguars game, which hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, while Indianapolis games have gone Over in six of the last 10 and Jacksonville's last contest also hit the Over. The Jaguars rank seventh in scoring at 25.7 points per game, matching the Chicago Bears, while the Colts are allowing 25.7 points per game after trading defensive lineman DeForest Buckner. Indianapolis relies on running back Jonathan Taylor, who has 587 yards and eight touchdowns on 140 carries, while quarterback Daniel Jones has thrown for 1,398 yards with four touchdowns and seven interceptions. Jacksonville's Trevor Lawrence has completed 65.2% of his passes for 1,480 yards, 14 touchdowns, and four interceptions, with a 106.3 rating; his top target Parker Washington has 26 catches for 416 yards and four touchdowns.
The model also identifies four other matchups where it believes the line is significantly off, including multiple spread picks hitting well over 50% of the time. The full Week 8 NFL best bets and parlay details are available through SportsLine.
