No. 12 Ohio State (6-2, 4-1 Big Ten) hosts No. 23 Oregon (5-3, 3-2 Big Ten) at Ohio Stadium in Columbus, Ohio, with kickoff set for 3:30 p.m. ET. The Buckeyes are 7.5-point favorites and the over/under sits at 44.5 points. Both starting quarterbacks are sidelined: Ohio State's Julian Sayin is out with an arm injury, while Oregon's Dante Moore is in concussion protocol. Receiver Brandon Inniss is listed as doubtful for the Buckeyes.
Model Predictions and Trends
The SportsLine Projection Model, which simulates each game 10,000 times, projects the over 44.5 points to hit in 56% of simulations. The last four meetings between the programs have all exceeded 60 combined points, and the over has cashed in all four Ohio State home games in 2026 as well as two of three Oregon road games. Oregon's backup quarterback Dylan Raiola threw for 336 yards and three touchdowns last week, while Ohio State true freshman Luke Fahey posted 260 yards, one touchdown and zero turnovers at USC. The model forecasts over 500 combined passing yards for Saturday and indicates one side of the spread hits in more than 60% of simulations. The model entered Week 10 with an 80-77 record on top-rated college football picks.
